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The Spectacular Collection is the newest collection of RSN where members from expert labs in their respective field talk about their latest discovery.

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Medium-density amorphous ice

04:40

Medium-density amorphous ice

Dr Micheal Davies from University College London and the University of Cambridge tells us the latest of a new form of ice that is suspected to be found in space.

Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function

03:48

Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function

Dr Vijay K. Kuchroo from Brigham and Women's hospital and Harvard Medical School describes how IL-33-ST2-AKT signaling is important for neurodevelopment and explains the implication of this axis in neuropsychiatric disorders. Review & Win! Please go to this link: shorturl.at/txLP7

Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity

04:16

Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity

Dr Kuchroo from Brigham and Women's hospital and Harvard Medical School describe how a specific population of Th17 cells serves as a reservoir for pathogenic Th17 cells contributing to the pathogenesis of Multiple Sclerosis. Link of full article: https://www.cell.com/cell/fulltext/S0092-8674(21)01333-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867421013337%3Fshowall%3Dtrue Review & Win! Please go to this link: shorturl.at/txLP7

Germinal centre-driven maturation of B cell response to mRNA vaccination

04:09

Germinal centre-driven maturation of B cell response to mRNA vaccination

Dr Jackson Turner from Ali Ellebedy lab at Washington University School of Medicine in St. Louis describes the evolution of B-cells following vaccination against Covid-19. Read the full article https://www.nature.com/articles/s41586-022-04527-1 Review & Win! Please go to this link: shorturl.at/txLP7

A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes

02:56

A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes

Dr Casanova from the Rockefeller University and University of Paris Cité discusses his latest findings regarding autosomal recessive IFNAR1 deficiency and it's impact o susceptibility of disease development found in the population of Western Polynesia. Read the full article https://rupress.org/jem/article/219/6/e20220028/213170/A-loss-of-function-IFNAR1-allele-in-Polynesia Review & Win! Please go to this link: shorturl.at/txLP7

Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancer

06:03

Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancer

Dr Josephine Giles from John Wherry's lab at University of Pennsylvania describes her latest findings on novel epigenetic and transcriptional regulation of human T cells and the application on different diseases. Read the full article https://www.cell.com/immunity/fulltext/S1074-7613(22)00084-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS107476132200084X%3Fshowall%3Dtrue Review & Win! Please go to this link: shorturl.at/txLP7

Massively parallel phenotyping of coding variants in cancer with Perturb-seq

06:19

Massively parallel phenotyping of coding variants in cancer with Perturb-seq

Dr Oana Orsu from Dr Aviv Regev lab at Genentech describes her latest findings on determining the function of a particular mutation from a specific target in the context of Cancer using the genetic approach Perturb-Seq. Read the full article https://www.nature.com/articles/s41587-021-01160-7 Review & Win! Please go to this link: shorturl.at/txLP7

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

04:29

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

The lab of Dr Jonathan Kipnis from Washington University School of Medicine in St. Louis presents recent findings on how the CNS communicated to recruit de novo immune cells, upon spinal injury. Read the full article https://www.nature.com/articles/s41593-022-01029-1 Review & Win! Please go to this link: shorturl.at/txLP7

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